“Once you've dissected a joke, you're about where you are when you've dissected a frog. It's dead.”

— Isaac Asimov , book Banquets of the Black Widowers

Banquets of the Black Widowers (1984), p. 49; comparable to "Humor can be dissected, as a frog can, but the thing dies in the process and the innards are discouraging to any but the pure scientific mind." — E. B. White, in "Some Remarks on Humor," preface to A Subtreasury of American Humor (1941)
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Isaac Asimov 303

American writer and professor of biochemistry at Boston Uni… 1920–1992

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“Humor can be dissected, as a frog can, but the thing dies in the process and the innards are discouraging to any but the pure scientific mind.”

E. B. White (1899–1985) American writer

"Some Remarks on Humor," preface to A Subtreasury of American Humor (1941)
A very similar remark is often attributed to White, but may actually be a paraphrased version of the above statement: "Analyzing humor is like dissecting a frog. Few people are interested and the frog dies of it."