“There is not a man who does not get senile by the time he reaches sixty. And when one thinks that he will not be senile, he is already so.”

— Tsunetomo Yamamoto , book Hagakure

Hagakure (c. 1716)

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Tsunetomo Yamamoto 65

Samurai 1659–1719

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“The first sign of senility is that a man forgets his theorems, the second sign is that he forgets to zip up, the third sign is that he forgets to zip down.”

Paul Erdős (1913–1996) Hungarian mathematician and freelancer

Though Erdős used this remark, it is said to have originated with his friend Stanisław Ulam, as reported in The Man Who Loved Only Numbers : The Story of Paul Erdős and the Search for Mathematical Truth (1998) by Paul Hoffman
Variants:
The first sign of senility is when a man forgets his theorems. The second sign is when he forgets to zip up. The third sign is when he forgets to zip down.
As quoted in Wonders of Numbers : Adventures in Mathematics, Mind, and Meaning (2002) by Clifford A. Pickover, p. 64
There are three signs of senility. The first sign is that a man forgets his theorems. The second sign is that he forgets to zip up. The third sign is that he forgets to zip down.
Misattributed

“The first sign of senility is that a man forgets his theorems, the second sign is that he forgets to zip up, the third sign is that he forgets to zip down.”

Stanislaw Ulam (1909–1984) Polish-American mathematician

Attributed in Paul Hoffman, The Man Who Loved Only Numbers: The Story of Paul Erdős and the Search for Mathematical Truth (1998)
This has also been attributed, with variants, to Paul Erdős, who repeated the remark.