“Susie: The way Calvin's brain is wired, you can almost hear the fuses blowing.
p64”

“Just as there are odors that dogs can smell and we cannot, as well as sounds that dogs can hear and we cannot, so too there are wavelengths of light we cannot see and flavors we cannot taste. Why then, given our brains wired the way they are, does the remark, "Perhaps there are thoughts we cannot think," surprise you?”

“Thanks to the way your brain is wired, you're likely to screw over your future in order to stay loyal to decisions you made in the past”

“(Television) The brain is differently wired in men and women. (Sylvia) In men, the wires are loose.”

“The only permanent rule in Calvinball is that you can never play it the same way twice! (Calvin)”

“Yuki: "Is your brain directly wired to perversion?”

“If the electrician who comes to mend my fuse blows it instead, so I should stop having electricity? I should cut off my light? Socialism is my light, can you understand that?”

“We are different because our brain is wired differently. This causes us to perceive the world in different ways and have different values and priorities. Not better or worse - different.”

“There are people who say "I'll never need this math, these trig identities from 10th grade or 11th grade," or maybe you never learned them. Here's the catch: whether or not you ever again use the math that you learned in school, the act of having learned the math established a wiring in your brain that didn't exist before and it's the wiring in your brain that makes you the problem solver.”

“I am fused, just in case I blow out. I am glued, just in case I crack out.”