“All the labor of all the ages, all the devotion, all the inspiration, all the noonday brightness of human genius are destined to extinction. So now, my friends, if that is true, and it is true, what is the point?”

From 1980s onwards, Critical Path (1981)

"Laughing with a Mouth of Blood"
Actor (2009)
Context: I traded my plot of land for a plane to anywhere
Oh where did you go.
And I can't see the future but I know it's watching me.
All my old friends aren't so friendly
And all my old haunts are now haunting me.

Source: Company Manners: A Cultural Inquiry into American Life (1954), p. 26.

2013, Speech: Nomination of Senator Ralph Recto as Senate Pro Tempore

Part I : Contemporary Issues in Science, Ch. 1 : "The Scientist as Rebel"; this first appeared in New York Review of Books (25 May 1995).
The Scientist As Rebel (2006)
Context: There is no such thing as a unique scientific vision, any more than there is a unique poetic vision. Science is a mosaic of partial and conflicting visions. But there is one common element in these visions. The common element is rebellion against the restrictions imposed by the locally prevailing culture, Western or Eastern as the case may be. It is no more Western than it is Arab or Indian or Japanese or Chinese. Arabs and Indians and Japanese and Chinese had a big share in the development of modern science. And two thousand years earlier, the beginnings of science were as much Babylonian and Egyptian as Greek. One of the central facts about science is that it pays no attention to East and West and North and South and black and yellow and white. It belongs to everybody who is willing to make the effort to learn it. And what is true of science is true of poetry.... Poetry and science are gifts given to all of humanity.

Source: " The Poet of Pessimism https://www.henrysalt.co.uk/library/essay/the-poet-of-pessimism/", Vegetarian Review, August 1896
Context: We work for an ideal, not because we believe the ideal is destined to be triumphant, but because we are impelled so to work, and cannot, without violence to our best instincts, act otherwise. We protest against cruelty and injustice for the same reason, not merely because we feel that the dawn of a better day is at hand, but because such a protest has to be made, and we know intuitively that we must help to make it. Of the event we can have no absolute assurance—it rests for other minds and other hands than our—but we can at least be assured that we have done what was natural and inevitable to us, and that, whether successful or unsuccessful, there was no other course for a thoughtful man to take.

Thus It Is, 1989, p. 1
As of a Trumpet, On Eagle's Wings, Thus It Is

It's Not Funny