“Doubt is the origin of wisdom”

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René Descartes 47
French philosopher, mathematician, and scientist 1596–1650

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Source: The Story of My Life (1932), Ch. 4 "Called To The Bar"

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“I found folly everywhere, but there were grains of wisdom in every stream of it. No doubt there was much more wisdom that I failed to recognize.”

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"Tell me again what your purpose is. You're going to find the bearer of this subtle knife, and what then?"
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“If I am fool, it is, at least, a doubting one; and I envy no one the certainty of his self-approved wisdom.”

George Gordon Byron (1788–1824) English poet and a leading figure in the Romantic movement

Journal for Saturday, 27th November 1813; Quoted in Letters and Journals of Lord Byron by Thomas Moore (1830), Vol III, Chap. XVII, p. 208 http://books.google.com/books?id=nloLAAAAIAAJ&pg=PA208

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“The wisdom of mankind creeps slowly on,
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“To say that the universe was here last year, or millions of years ago, does not explain its origin. This is still a mystery. As to the question of the origin of things, man can only wonder and doubt and guess.”

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Why I Am An Agnostic (1929)
Context: To say that God made the universe gives us no explanation of the beginnings of things. If we are told that God made the universe, the question immediately arises: Who made God? Did he always exist, or was there some power back of that? Did he create matter out of nothing, or is his existence coextensive with matter? The problem is still there. What is the origin of it all? If, on the other hand, one says that the universe was not made by God, that it always existed, he has the same difficulty to confront. To say that the universe was here last year, or millions of years ago, does not explain its origin. This is still a mystery. As to the question of the origin of things, man can only wonder and doubt and guess.

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Source: Retaliation (1774), Line 24.

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