“General systems theory is a set of related definitions, assumptions, and propositions which deal with reality as an integrated hierarchy of organizations of matter and energy. General systems behavior is concerned with a special subset of all systems, the living ones.
Even more basic to this presentation than the concept of "system" are the concepts of "space," "time," "matter," "energy," and "information," because the living systems which I shall discuss exist in space and are made of matter and energy organized by information.”

—  James Grier Miller

Source: Living Systems: Basic Concepts (1969), p. 51; Opening paragraph

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James Grier Miller 24
biologist 1916–2002

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“The most general form of systems theory is a set of logical or mathematical statements about all conceptual systems. A subset of this concerns all concrete systems. A subsubset concerns the very special and very important living systems, i. e., general living systems theory.”

James Grier Miller (1916–2002) biologist

Source: Living systems, 1978, p. 41

“General systems theory is a series of related definitions, assumptions, and postulates about all levels of systems from atomic particles through atoms, molecules, crystals, viruses, cells, organs, individuals, small groups, societies, planets, solar systems, and galaxies. General behavior systems theory is a subcategory of such theory, dealing with living systems, extending roughly from viruses through societies. A significant fact about living things is that they are open systems, with important inputs and outputs. Laws which apply to them differ from those applying to relatively closed systems.”

James Grier Miller (1916–2002) biologist

Miller (1956) "General behavior systems theory and summary". In: Journal of Counseling Psychology. 3 (2) 120-124. Cited in: Francis Ferguson (1975) Architecture, cities and the systems approach. p. 12

Béla H. Bánáthy photo

“Systems theory pursues the scientific exploration and understanding of systems that exist in the various realms of experience, in order to arrive at a general theory of systems: an organized expressing of sets of interrelated concepts and principles that apply to all systems.”

Béla H. Bánáthy (1919–2003) Hungarian linguist and systems scientist

Source: Systems Design of Education (1991), p. 31

“My presentation of a general theory of living systems will employ two sorts of spaces in which they may exist, physical or geographical space and conceptual or abstract space…
The characteristics and constraints of physical space affect the action of all concrete systems, living and nonliving… Physical space is a common space because it is the only space in which all concrete systems, living and nonliving, exist (though some may exist in other spaces simultaneously). Physical space is shared by all scientific observers, and all scientific data must be collected in it. This is equally true for natural science and behavioral science.”

James Grier Miller (1916–2002) biologist

Source: Living systems, 1978, p. 9-10; As cited in: Kenneth D. Bailey (1994) Sociology and the New Systems Theory: Toward a Theoretical Synthesis. p. 262

“Since it can be argued that both science and engineering are concerned with the study of real systems and their behavior, it follows that a general theory should be concerned with the study of general systems… It suffices for the present discussion to consider a general system as an abstract analogue or model of a class of real systems. General systems theory is then a theory of general models.”

Mihajlo D. Mesarovic (1928) Serbian academic

Mesarovic (1964) cited in: Shatrughna P. Sinha (1991) Instant encyclopaedia of geography. 1. Introduction to geography. Mittal Publications, p. 467

“The purpose of this book is to discuss and present evidence for the general thesis that the flow of energy through a system acts to organize that system.”

Harold J. Morowitz (1927–2016) American biophysicist

Energy Flow in Biology: Biological Organization as a Problem in Thermal Physics (1968), p. 2.
Italics are in the original. Later quoted on the inside front cover of The Last Whole Earth Catalog.

“Thus, there exist models, principles, and laws that apply to generalized systems or their subclasses, irrespective of their particular kind, the nature of their component elements, and the relations or „forces‟ between them. It seems legitimate to ask for a theory, not of systems of a more or less special kind, but of universal principles applying to systems in general. In this way, we postulate a new discipline called General Systems Theory. Its subject matter is the formulation and derivation of those principles, which are valid for „systems‟ in general.”

Ludwig von Bertalanffy (1901–1972) austrian biologist and philosopher

Source: General System Theory (1968), 2. The Meaning of General Systems Theory, p. 32

“General systems theory deals with the most fundamental concepts and aspects of systems. Many theories dealing with more specific types of systems (e. g., dynamical systems, automata, control systems, game-theoretic systems, among many others) have been under development for quite some time. General systems theory is concerned with the basic issues common to all these specialized treatments. Also, for truly complex phenomena, such as those found predominantly in the social and biological sciences, the specialized descriptions used in classical theories (which are based on special mathematical structures such as differential or difference equations, numerical or abstract algebras, etc.) do not adequately and properly represent the actual events. Either because of this inadequate match between the events and types of descriptions available or because of the pure lack of knowledge, for many truly complex problems one can give only the most general statements, which are qualitative and too often even only verbal. General systems theory is aimed at providing a description and explanation for such complex phenomena.”

Mihajlo D. Mesarovic (1928) Serbian academic

Mihajlo D. Mesarovic and Y. Takahare (1975) General Systems Theory, Mathematical foundations. Academic Press. Cited in: Franz Pichler, Roberto Moreno Diaz (1993. Computer Aided Systems Theory. p. 134

“Concepts like those of organization, wholeness, directiveness, teleology, control, self-regulation, differentiation, and the like are alien to conventional science. However, they pop up everywhere in the biological, behavioral, and social sciences and are, in fact, indispensable for dealing with living organisms or social groups. Thus, a basic problem posed to modem science is a general theory of organization. General Systems Theory is, in principle, capable of giving exact definitions for such concepts.”

Ludwig von Bertalanffy (1901–1972) austrian biologist and philosopher

1950s, "General systems theory," 1956

“The universe of all things that exist may be understood as a universe of systems where a system is defined as any set of related and interacting elements. This concept is primitive and powerful and has been used increasingly over the last half-century to organize knowledge in virtually all domains of interest to investigators. As human inventions and social interactions grow more complex, general conceptual frameworks that integrate knowledge among different disciplines studying those emerging systems grow more important. Living systems theory (LST) instructs integrative research among biological and social sciences and related academic disciplines.”

James Grier Miller (1916–2002) biologist

G. A. Swanson and James Grier Miller (2013) " Living Systems Theory http://www.eolss.net/Sample-Chapters/C02/E6-46-01-03.pdf" in Systems Science and Cybernetics. Vol I.

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