“What kills a person at twenty-five? Leukemia. An accident. But George knows the better odds are that someone who passes at that age dies of unhappiness. Drug overdose. Suicide. Reckless behavior.”

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Drugs

Variant: It's far better to be unhappy alone than unhappy with someone — so far.
Source: On Being Blonde (2007), p. 52

Source: Whispers Under Ground (2012), Chapter 21, “Oxford Circus” (p. 226)

Truth Behind the Fantasy of Porn: The Greatest Illusion on Earth (2010), Dedication

Every Person
Lyrics, Shadows Collide with People (2004)

The War On Drugs Is Lost (1995)
Context: More people die every year as a result of the war against drugs than die from what we call, generically, overdosing. These fatalities include, perhaps most prominently, drug merchants who compete for commercial territory, but include also people who are robbed and killed by those desperate for money to buy the drug to which they have become addicted.
This is perhaps the moment to note that the pharmaceutical cost of cocaine and heroin is approximately 2 per cent of the street price of those drugs. Since a cocaine addict can spend as much as $1,000 per week to sustain his habit, he would need to come up with that $1,000. The approximate fencing cost of stolen goods is 80 per cent, so that to come up with $1,000 can require stealing $5,000 worth of jewels, cars, whatever. We can see that at free-market rates, $20 per week would provide the addict with the cocaine which, in this wartime drug situation, requires of him $1,000.

"Introduction"
The Defendant (1901)
Context: The pessimist is commonly spoken of as the man in revolt. He is not. Firstly, because it requires some cheerfulness to continue in revolt, and secondly, because pessimism appeals to the weaker side of everybody, and the pessimist, therefore, drives as roaring a trade as the publican. The person who is really in revolt is the optimist, who generally lives and dies in a desperate and suicidal effort to persuade all the other people how good they are. It has been proved a hundred times over that if you really wish to enrage people and make them angry, even unto death, the right way to do it is to tell them that they are all the sons of God.

Real Time with Bill Maher, 25 February 2005