“The only thing you can do easily is be wrong, and that's hardly worth the effort.”

1900s, Address at the Prize Day Exercises at Groton School (1904)
Context: Of course, the worst of all lives is the vicious life; the life of a man who becomes a positive addition to the forces of evil in a community. Next to that and when I am speaking to people who, by birth and training and standing, ought to amount to a great deal, I have a right to say only second to it in criminality comes the life of mere vapid ease, the ignoble life of a man who desires nothing from his years but that they shall be led with the least effort, the least trouble, the greatest amount of physical enjoyment or intellectual enjoyment of a mere dilettante type. The life that is worth living, and the only life that is worth living, is the life of effort, the life of effort to attain what is worth striving for.

The Powerbook (2000)

Women Talking Dirty

The Wall Street Journal, November 20, 2009, "Hollywood's Favorite Cowboy" http://online.wsj.com/article/SB10001424052748704576204574529703577274572.html by John Jurgensen <!--accessed: November 17, 2009-->
Variant: I’m not interested in writing short stories. Anything that doesn’t take years of your life and drive you to suicide hardly seems worth doing.
Context: I'm not interested in writing short stories. Anything that doesn't take years of your life and drive you to suicide hardly seems worth doing.

As quoted by John M. Kost http://www.mackinac.org/bio.aspx?ID=104 (25 July 1995) in S. 946, the Information Technology Management Reform Act of 1995: hearing before the Subcommittee on Oversight of Government Management and the District of Columbia of the Committee on Governmental Affairs (1996).
This appears to derive from a 1910 advertisement by writer Alfred Henry Lewis for a forthcoming series of biographical articles about Roosevelt: "All activity, Mr. Roosevelt has often shown that it is better to do the wrong thing than do nothing at all. In politics this last is peculiarly true. The best thing is to do the right thing; the next best is to do the wrong thing; the worst thing of all things is to stand perfectly still". (e.g. in La Follette's Magazine https://books.google.com/books?id=RV4CAAAAIAAJ&pg=PA183&dq=%22best+thing%22+%22right+thing%22+%22worst+thing%22+nothing&hl=en&sa=X&ved=0ahUKEwjNksu-nZrMAhVDy2MKHSl1Df8Q6AEIIzAB#v=onepage&q=%22the%20best%20thing%20is%20to%20do%20the%20right%20thing%22&f=false (28 May 1910)
Disputed

Guide to Kulchur (1938), p. 60

Epigrams on Programming, 1982

Source: Thinking and Destiny (1946), Ch. 14, Thinking: The Way to Conscious Immortality, p. 943