“In addition to preventing many chronic diseases … comprehensive lifestyle changes can often reverse the progression of these illnesses. … Changing lifestyle actually changes your genes—turning on genes that keep you healthy, and turning off genes that promote heart disease, prostate cancer, breast cancer, and diabetes—more than five hundred genes in only three months. People often say, “Oh, it's all in my genes. There's not much I can do about it.” But there is. Knowing that changing lifestyle changes our genes is often very motivating—not to blame, but to empower. … [Our approach is] not like there was one set of dietary recommendations for reversing heart disease, a different one for reversing diabetes, and yet another for changing your genes or lengthening your telomeres. In all of our studies, people were asked to consume a whole-foods, plant-based diet … It's as though your body knows how to personalize the medicine it needs if you give it the right raw materials in your diet and lifestyle. … And what's good for you is good for our planet. To the degree we transition toward a whole-foods, plant-based diet, it not only makes a difference in our own lives; it also makes a difference in the lives of many others across the globe.”

— Dean Ornish

Introduction https://books.google.it/books?id=KfeoBAAAQBAJ&pg=PP12 to Marco Borges, The 22-Day Revolution (New York: Penguin, 2015).

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Dean Ornish 5

American physician 1953

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“When you eat a healthy, whole foods, plant-based diet, it changes the expression of your genes. It turns on the good genes, turns off the bad genes. Your genes are a predisposition, but your genes are not your fate. And even if your mother and your father and aunts and uncles all died of diabetes, cancer, even heart disease, it doesn't mean that you need to.”

Dean Ornish (1953) American physician

Interview in the documentary-film The Game Changers by Louie Psihoyos (2018).

“I think of genes in two ways. There are dictator genes. Those genes give orders—blue eyes or brown hair—and you don't have any choice. The genes for diabetes, heart disease, or certain forms of cancer, they're more like committees giving suggestions. But you've got a lot of control over whether those genes ever express themselves. The vista on diet-related disease is spreading out in a bigger way than we ever imagined. We thought maybe diet affected heart disease and a few cancers. Then there was diabetes. Now it's also brain disease—not only stroke but also Alzheimer's. We thought that was entirely due to genes and age. Now we know it's due, to a very substantial degree, to diet. We've got control. Not perfect control, but certainly control we never had before.”

Neal D. Barnard (1953) American physician, author, and clinical researcher

Interview in the book What the Health https://books.google.it/books?id=FIY8DgAAQBAJ&pg=PT0 by Eunice Wong (Xlibris, 2017), ch. 1.

Michael Greger (1972) American physician, author, and vegan health activist

Interview in the documentary-film What the Health by Kip Andersen (2017).

“We can actually change the expression of genes—tumor suppressing genes, tumor activating genes—by what we eat, what we put into our bodies. So, even if you've been dealt a bad genetic deck, you can still reshuffle it with diet. … When you’re treating diseases with drugs, you know there’s one drug you take for cholesterol, a different class of drugs you take for high blood pressure, different class of drugs you take for diabetes, but, with diet, a plant-based diet affects all these diseases. One diet to kinda rule them all.”

Michael Greger (1972) American physician, author, and vegan health activist

Interview in the documentary-film What the Health by Kip Andersen (2017).

“Jacob and Monod not only outlined a theory of gene regulation, they also discovered the first regulators of gene transcription. These regulators come in two forms—repressors, genes that encode the regulatory proteins that shut genes off, and as later work showed, activators, genes that encode the regulatory proteins that turn genes on.”

Eric R. Kandel (1929) American neuropsychiatrist

In Search of Memory (2006)

“I was attracted to studies of cancer families because epidemiological studies show that virtually all cancers manifest a tendency to aggregate in families. Close relatives of a cancer patient are at increased risk of that neoplasm, and perhaps other forms of cancer. The excess site-specific cancer risk is exceptionally high for carriers of certain cancer genes, in whom the attack rate can approach 100 percent. In candidate cancer families, the possibility that clustering is on the basis of chance must be excluded through epidemiological studies that establish the presence of an excess cancer risk. Predisposed families are candidates for laboratory studies to identify the inherited susceptibility factors. These investigations have led to the identification and isolation of human cancer genes, the tumor suppressor genes. These cancer genes are among more than 200 single-gene traits associated with the development of cancer. Approximately a dozen inherited susceptibility genes have been definitively identified, and many more are being sought. From studies of retinoblastoma and other rare cancers, important new information was generated about the fundamental biology of cancers that arise in many patients. Isolation of an inherited cancer susceptibility gene provides opportunities for presymptomatic testing of at-risk relatives. However, testing of healthy individuals also raise important issues regarding informed consent, confidentiality and potential for adverse psychological, social and economic effects.”

Frederick Pei Li (1940–2015) American physician

Frederick Li - Harvard T.H. Chan School of Public Health http://www.hsph.harvard.edu/frederick-li/.

““I see what Gene is driving at. To dream of changing the whole universe in accordance with a set of local preconceptions!… Oh, it’s ridiculous!”
“A missionary,” Gene repeated with a solemn nod. “By definition: a person who does without intending it more harm than good.””

John Brunner book The Tides of Time

Source: The Tides of Time (1984), Chapter 12 (p. 220)

“It may come as a surprise to many people that the human genome contains human endogenous retroviruses (HERVs) that are linked to cancer, autoimmune diseases, multiple sclerosis, schizophrenia, and more. Gene editing offers a new hope to eradicating many deadly hereditary diseases.”

Newton Lee American computer scientist

Google It: Total Information Awareness, 2016

“Jacob and Monod found that in bacteria, genes are switched on and off by other genes. This led them to distinguish between effector genes and regulatory genes. Effector genes encode effector proteins… which mediate specific cellular functions. Regulatory genes encode proteins called regulatory proteins, which switch the effector genes on or off.”

Eric R. Kandel (1929) American neuropsychiatrist

In Search of Memory (2006)

“The idea that a few people have about the gene being the target of selection is completely impractical; a gene is never visible to natural selection, and in the genotype, it is always in the context with other genes, and the interaction with those other genes make a particular gene either more favorable or less favorable. In fact, Dobzhanksy, for instance, worked quite a bit on so-called lethal chromosomes which are highly successful in one combination, and lethal in another. Therefore people like Dawkins in England who still think the gene is the target of selection are evidently wrong. In the 30s and 40s, it was widely accepted that genes were the target of selection, because that was the only way they could be made accessible to mathematics, but now we know that it is really the whole genotype of the individual, not the gene. Except for that slight revision, the basic Darwinian theory hasn't changed in the last 50 years”

Ernst Mayr (1904–2005) German-American Evolutionary Biologist

Part of the answer to the question "Where do you think Darwinism is going to go in the next 50 years?"
What evolution is: Talk with Ernst Mayr (2001)

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