If he insists in having every last theoretical T crossed before he starts his research the chances are that he will never do a significant experiment. And the more significant and fundamental the experiment the more theoretical uncertainty may be tolerated. By contrast, the more important and difficult the experiment the more that experimental care is warranted. There is no point in attempting a half-hearted experiment with an inadequate apparatus.
as quoted by [W. Happer, P. J. E. Peebles, and D. T. Wilkinson, Biographical Memoirs, Robert Henry Dicke May 6, 1916 — March 4, 1997, http://www.nap.edu/readingroom/books/biomems/rdicke.html]
“I have long believed that an experimentalist should not be unduely inhibited by theoretical untidyness. If he insists in having every last theoretical T crossed before he starts his research the chances are that he will never do a significant experiment. And the more significant and fundamental the experiment the more theoretical uncertainty may be tolerated. By contrast, the more important and difficult the experiment the more that experimental care is warranted. There is no point in attempting a half-hearted experiment with an inadequate apparatus.”
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Robert H. Dicke 2
American astronomer 1916–1997Related quotes

“The teaching of mathematics,” p. 71-72
On Science, Necessity, and the Love of God (1968)
Context: My purpose here is to denounce an idea which seems to be dangerous and false. … Revolutionary trade unionists and orthodox communists are at one in considering everything that is purely theoretical as bourgeois. … The culture of a socialist society would be a synthesis of theory and practice; but to synthesize is not the same as to confuse together; it is only contraries that can be synthesized. … Marx’s principal glory is to have rescued the study of societies not only from Utopianism but also and at the same time from empiricism. … Humanity cannot progress by importing into theoretical study the processes of blind routine and haphazard experiment by which production has so long been dominated. … The true relation between theory and application only appears when theoretical research has been purged of all empiricism.

Source: The Courage to Create (1975), Ch. 7 : Passion for Form, p. 131
Context: The human imagination leaps to form the whole, to complete the scene in order to make sense of it. The instantaneous way this is done shows how we are driven to construct the remainder of the scene. To fill the gaps is essential if the scene is to have meaning. That we may do this in misleading ways — at times in neurotic or paranoid ways — does not gainsay the central point. Our passion for form expresses our yearning to make the world adequate to our needs and desires, and, more important, to experience ourselves as having significance.

conjecture
in his Nobel Lecture http://nobelprize.org/nobel_prizes/chemistry/laureates/1996/curl-lecture.html, December 7, 1996, Dawn of the Fullerenes: Experiment and Conjecture

Trygve Haavelmo, "The probability approach in econometrics" in: Supplement to Econometrica. 12 91944), p. 5; Cited in Pearl (2012, 1-2)

Source: [Wiener, N., A New Theory of Measurement: A Study in the Logic of Mathematics, Proceedings of the London Mathematical Society, s2-19, 1, 1921, 181–205, 0024-6115, 10.1112/plms/s2-19.1.181]

“Every time man makes a new experiment he always learns more. He cannot learn less.”
1960s, Operating Manual for Spaceship Earth (1963)
Context: Every time man makes a new experiment he always learns more. He cannot learn less. He may learn that what he thought was true was not true. By the elimination of a false premise, his basic capital wealth which in his given lifetime is disembarrassed of further preoccupation with considerations of how to employ a worthless time-consuming hypothesis. Freeing his time for its more effective exploratory investment is to give man increased wealth.