On the question "When and what was responsible for you becoming interested in your academic discipline?" http://www.kcl.ac.uk/aboutkings/governance/equality/meettheprofessors/artshums/mantognazza.aspx, at kcl.ac.uk, 2015.
“The question whether we have not some knowledge independent of any and all experience — whether there must not, unavoidably, be some knowledge a priori, some knowledge which we come at simply by virtue of our nature — is really the paramount question, around which the whole conflict in philosophy concentrates, and on the decision of which the settlement of every other question hangs. To cast the career of a philosophy upon a negative answer to it, as if this were a matter of course, — which the English school from Hobbes onward has continually done, — is to proceed not only upon a petitio, but upon a delusion regarding the security of the road.”
Source: The Limits of Evolution, and Other Essays, Illustrating the Metaphysical Theory of Personal Ideaalism (1905), The Limits of Evolution, p.17
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George Holmes Howison 135
American philosopher 1834–1916Related quotes
What is Knowledge? (1971)

"Critique of the Physical Concepts of the Corpuscular Theory" in The Physical Principles of the Quantum Theory (1930) as translated by Carl Eckhart and Frank C. Hoyt, p. 20; also in "The Uncertainty Principle" in The World of Mathematics : A Small Library of the Literature of Mathematics (1956) by James Roy Newman, p. 1051

I.
Outline of the Doctrine of Knowledge (1810)
Context: The Doctrine of Knowledge, apart from all special and definite knowing, proceeds immediately upon Knowledge itself, in the essential unity in which it recognises Knowledge as existing; and it raises this question in the first place — How this Knowledge can come into being, and what it is in its inward and essential Nature?
The following must be apparent: — There is but One who is absolutely by and through himself, — namely, God; and God is not the mere dead conception to which we have thus given utterance, but he is in himself pure Life. He can neither change nor determine himself in aught within himself, nor become any other Being; for his Being contains within it all his Being and all possible Being, and neither within him nor out of him can any new Being arise.

"On the Atomic Theory," J. Chem. Soc., 2nd Ser., 1869, 7:328-365, on p. 365.

1840s, Essays: First Series (1841), Self-Reliance

Source: Course of Experimental Philosophy, 1745, p. v: Preface
Context: All the knowledge we have of nature depends upon facts; for without observations and experiments our natural philosophy would only be a science of terms and an unintelligible jargon. But then we must call in Geometry and Arithmetics, to our Assistance, unless we are willing to content ourselves with natural History and conjectural Philosophy. For, as many causes concur in the production of compound effects, we are liable to mistake the predominant cause, unless we can measure the quantity and the effect produced, compare them with, and distinguish them from, each other, to find out the adequate cause of each single effect, and what must be the result of their joint action.

The Procedural Republic and the Unencumbered Self, 1984

Friedrich Hayek (1991). "On being an economist." In: W. W. Bartley and S. Kresge (eds.), The Trend of Economic Thinking; Essays on Political Economists and Economic History, Volume III, London. Routledge. p. 38
1980s and later
“If we would have new knowledge, we must get us a whole world of new questions.”
Philosophy in a New Key (1941)