“All beings want to be happy, yet so very few know how. It is out of ignorance that any of us cause suffering, for ourselves or for others”

Source: 60 Years A Priest: An Interview with Archbishop Alfred Hughes https://nds.edu/blog-entry/60-years-a-priest-an-interview-with-archbishop-alfred-hughes/

Suffering
Source: I am That, P.116.

Nobel acceptance speech (1989)
Context: I believe all suffering is caused by ignorance. People inflict pain on others in the selfish pursuit of their happiness or satisfaction. Yet true happiness comes from a sense of inner peace and contentment, which in turn must be achieved through the cultivation of altruism, of love and compassion and elimination of ignorance, selfishness and greed.
The problems we face today, violent conflicts, destruction of nature, poverty, hunger, and so on, are human-created problems which can be resolved through human effort, understanding and the development of a sense of brotherhood and sisterhood. We need to cultivate a universal responsibility for one another and the planet we share. Although I have found my own Buddhist religion helpful in generating love and compassion, even for those we consider our enemies, I am convinced that everyone can develop a good heart and a sense of universal responsibility with or without religion.

Context: From the moment of birth every human being wants happiness and freedom and wants to avoid suffering. In this we are all the same; and the more we care for the happiness of others the greater our own sense of each other becomes. Many of our problems are created by ourselves based on divisions due to ideology, religion, race, resources, economic status or other factors. The time has come to think on a deeper, more human level and appreciate and respect our sameness as human beings. And to have a respect for endangered cultures that share these principles. We are at the dawn of an age in which many people feel that extreme political concepts should cease to dominate human affairs. We should use this opportunity to replace them with universal human and spiritual values and ensure that these values become the fiber of the global family that is emerging. It is not possible to find peace with anger, hatred, jealousy or greed. At every level of society, familial, tribal, national and international, the key to a happier and more peaceful and successful world is the growth of compassion. We do not necessarily need to become religious, nor even believe in an ideology. We need only to develop our good human qualities and know that love and compassion are the most essential concepts for human survival. So long as human beings live and suffer, the only world open to our present knowledge, the brotherhood of man will seem an unattainable principle. In order for us to achieve real lasting peace among one another, the effort to realize that noblest and most satisfactory moral value must be occupation of every individual intelligence.

The Compassionate Life (2001) Ch. 3 "Global Compassion".

"On the Roof of the World", Liberty Bell magazine (December 1987)
1970s, 1980s

Mūlamadhyamakakārikā 14.8–9
trans. Jay Garfield, The Fundamental Wisdom of the Middle Way (1995), ISBN 0195093364

Source: Time to Let Go

The trial of Charles B. Reynolds for blasphemy (1887)

Source: The New Ethics (1907), The Survival of the Strenuous, p. 167