“As a consequence of disease and environmental forces, as well as other factors, a large number of polymorphisms may exist in a population. Some may be related to present selective forces, and others to forces which operated in the past, but which are no longer significant. Present gene frequencies may also result from gene mixture between populations.”

[Polymorphisms of the serum proteins and the development of iso-preciptins in transfused patients, Bulletin of the New York Academy of Medicine, 40, 5, 1964, 377–386, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1750599/?page=2] (quote from 378)

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Baruch Samuel Blumberg 1
American doctor 1925–2011

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