“How do you know what's truly good if you've never experienced what's truly bad?”
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“What do you despise? By this you are truly known.”
A few sites, perhaps most of them deriving their information from its previous placement among the "Attributed" quotes here, credit this to Michelangelo, but so far as definite citations go, it almost certainly originated with Frank Herbert when he used the phrase in the novel Dune (1965).
Misattributed

“The critical task is necessarily comparative, and younger people do not truly know what is new.”
Going Steady (1969), Trash, Art and the Movies (February 1969)

“So long as you do not quarrel with sin, you will never be a truly happy man.”
Source: Dictionary of Burning Words of Brilliant Writers (1895), P. 297.

Preofections - Irene Dunne, by Elizabth Wilson; Silver Screen (November 1936) http://www.irenedunnesite.com/press/silver-screen-november-1936/.