“The Roman Catholic doctrine of transubstantiation… claims… the "Whole substance" of the wine is converted into the blood of Christ,; the appearance of wine that remains is "merely accidental", "inhering in no substance". Transubstantiation is colloquially taught as meaning that the wine "literally" turns into the blood of Christ. Whether in its obfuscatory Aristotelian or its franker colloquial form, the claim of transubstantiation can be made only if we do serious violence to the normal meanings of words like 'substance' and 'literally'.”

"Viruses of the Mind"
A Devil's Chaplain (2003)

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English ethologist, evolutionary biologist and author 1941

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“I don't believe you until you tell me, do you really believe, for example, if they say they are Catholic, "Do you really believe that when a priest blesses a wafer, it turns into the body of Christ? Are you seriously telling me you believe that? Are you seriously saying that wine turns into blood?"”

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Mock them. Ridicule them. In public. Don't fall for the convention that we're all too polite to talk about religion. Religion is not off the table. Religion is not off limits. Religion makes specific claims about the universe which need to be substantiated and need to be challenged and, if necessary, need to be ridiculed with contempt.
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“I called the Navab's wine blood,”

Laxmi Prasad Devkota (1909–1959) Nepali poet

Lunatic. 5
पागल (The Lunatic)
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“The Protestant churches generally hold that the elements of the sacrament are flesh and blood only in a tropical sense; they nourish our souls as meat and the juice of it would our bodies. But the Catholics maintain that they are literally just that; although they possess all the sensible qualities of wafer-cakes and diluted wine. But we can have no conception of wine except what may enter into a belief, either —
# That this, that, or the other, is wine; or,
# That wine possesses certain properties.
Such beliefs are nothing but self-notifications that we should, upon occasion, act in regard to such things as we believe to be wine according to the qualities which we believe wine to possess. The occasion of such action would be some sensible perception, the motive of it to produce some sensible result. Thus our action has exclusive reference to what affects the senses, our habit has the same bearing as our action, our belief the same as our habit, our conception the same as our belief; and we can consequently mean nothing by wine but what has certain effects, direct or indirect, upon our senses; and to talk of something as having all the sensible characters of wine, yet being in reality blood, is senseless jargon. Now, it is not my object to pursue the theological question; and having used it as a logical example I drop it, without caring to anticipate the theologian's reply. I only desire to point out how impossible it is that we should have an idea in our minds which relates to anything but conceived sensible effects of things. Our idea of anything is our idea of its sensible effects; and if we fancy that we have any other we deceive ourselves, and mistake a mere sensation accompanying the thought for a part of the thought itself. It is absurd to say that thought has any meaning unrelated to its only function. It is foolish for Catholics and Protestants to fancy themselves in disagreement about the elements of the sacrament, if they agree in regard to all their sensible effects, here or hereafter.
It appears, then, that the rule for attaining the third grade of clearness of apprehension is as follows: Consider what effects, which might conceivably have practical bearings, we conceive the object of our conception to have. Then, our conception of these effects is the whole of our conception of the object.”

Charles Sanders Peirce (1839–1914) American philosopher, logician, mathematician, and scientist

The final sentence here is an expression of what became known as the Pragmatic maxim, first published in "Illustrations of the Logic of Science" in Popular Science Monthly, Vol. 12 (January 1878), p. 286

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