http://www.gravett.org/bizarrescience/archives/003967.html
Letter to the Wall Street Journal
“The day of the last hypothesis would be also the day of the last observation… An hypothesis displaced by new facts dies an honorable death. If it has itself summoned to its trial the facts by which it is annihilated, it deserves even a monument of gratitude.”
Handbook of Rational Pathology, 1846-1853
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Jacob Henle 2
German physician, anatomist, and zoologist 1809–1885Related quotes
Source: "The Scientific Character of Geology," 1961, p. 454; As cited in: Alberta Research Council, Research Council of Alberta (1964), Bulletin - Alberta Research Council. Vol. 15-17, p. 31

“The great tragedy of Science — the slaying of a beautiful hypothesis by an ugly fact.”
Presidential Address at the British Association, "Biogenesis and abiogenesis" (1870) http://aleph0.clarku.edu/huxley/CE8/B-Ab.html; later published in Collected Essays, Vol. 8, p. 229
1870s
Source: Cider with Rosie (1959), p. 262.

p. 82 of How Much Can We Boost IQ and Scholastic Achievement? (1969) https://en.wikipedia.org/wiki/How_Much_Can_We_Boost_IQ_and_Scholastic_Achievement%3F, the invited paper that created much hostility towards Jensen.

Source: A Neglected Argument for the Reality of God (1908), II
Context: The hypothesis of God is a peculiar one, in that it supposes an infinitely incomprehensible object, although every hypothesis, as such, supposes its object to be truly conceived in the hypothesis. This leaves the hypothesis but one way of understanding itself; namely, as vague yet as true so far as it is definite, and as continually tending to define itself more and more, and without limit. The hypothesis, being thus itself inevitably subject to the law of growth, appears in its vagueness to represent God as so, albeit this is directly contradicted in the hypothesis from its very first phase. But this apparent attribution of growth to God, since it is ineradicable from the hypothesis, cannot, according to the hypothesis, be flatly false. Its implications concerning the Universes will be maintained in the hypothesis, while its implications concerning God will be partly disavowed, and yet held to be less false than their denial would be. Thus the hypothesis will lead to our thinking of features of each Universe as purposed; and this will stand or fall with the hypothesis. Yet a purpose essentially involves growth, and so cannot be attributed to God. Still it will, according to the hypothesis, be less false to speak so than to represent God as purposeless.

Source: 1860s, Evidence as to Man's Place in Nature (1863), Ch.2, p. 127