“The day of the last hypothesis would be also the day of the last observation… An hypothesis displaced by new facts dies an honorable death. If it has itself summoned to its trial the facts by which it is annihilated, it deserves even a monument of gratitude.”

Handbook of Rational Pathology, 1846-1853

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Jacob Henle2

German physician, anatomist, and zoologist 1809–1885

David Douglass

http://www.gravett.org/bizarrescience/archives/003967.html
Letter to the Wall Street Journal

“The functional validity of a working hypothesis is not a priori certain, because often it is initially based on intuition. However, logical deductions from such a hypothesis provide expectations (so called prognoses) as to the circumstances under which certain phenomena will appear in nature. Such a postulate or working hypothesis can then be substantiated by additional observations or by experiments especially arranged to test details. The value of the hypothesis is strengthened if the observed facts fit the expectation within the limits of permissible error.”

Reinout Willem van Bemmelen (1904–1983) Dutch geologist

Source: "The Scientific Character of Geology," 1961, p. 454; As cited in: Alberta Research Council, ‎Research Council of Alberta (1964), Bulletin - Alberta Research Council. Vol. 15-17, p. 31

“The great tragedy of Science — the slaying of a beautiful hypothesis by an ugly fact.”

Thomas Henry Huxley (1825–1895) English biologist and comparative anatomist

Presidential Address at the British Association, "Biogenesis and abiogenesis" (1870) http://aleph0.clarku.edu/huxley/CE8/B-Ab.html; later published in Collected Essays, Vol. 8, p. 229 <br class="br">1870s

“(Coining phrase "null hypothesis") In relation to any experiment we may speak of this hypothesis as the “null hypothesis,” and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.”

Ronald Fisher book The Design of Experiments

The Design of Experiments, Edinburgh: Oliver and Boyd, 1935, p. 18
1930s

“The last days of my childhood were also the last days of the village. I belonged to that generation which saw, by chance, the end of a thousand years' life.”

Laurie Lee book Cider with Rosie

Source: Cider with Rosie (1959), p. 262.

“H. A. Lorentz has found out the Relativity theorem and has created the Relativity postulate as a hypothesis that electrons and matter suffer contractions in consequence of their motion according to a certain law. A. Einstein has brought out the point very clearly, that this postulate is not an artificial hypothesis but is rather a new way of comprehending the time-concept, which is forced upon us by observation of natural phenomena.”

Hermann Minkowski The Fundamental Equations for Electromagnetic Processes in Moving Bodies

The Fundamental Equations for Electromagnetic Processes in Moving Bodies (1907)

“The fact that a reasonable hypothesis has not been rigorously proved does not mean that it should be summarily dismissed. It only means that we need more appropriate research for putting it to the test. I believe such definitive research is entirely possible but has not yet been done. So all we are left with are various lines of evidence, no one of which is definitive alone, but which, viewed all together, make it a not unreasonable hypothesis that genetic factors are strongly implicated in the average Negro-white intelligence difference. The preponderance of the evidence is, in my opinion, less consistent with a strictly environmental hypothesis than with a genetic hypothesis, which, of course, does not exclude the influence of environment or its interaction with genetic factors.”

Arthur Jensen (1923–2012) professor of educational psychology

p. 82 of How Much Can We Boost IQ and Scholastic Achievement? (1969) https://en.wikipedia.org/wiki/How_Much_Can_We_Boost_IQ_and_Scholastic_Achievement%3F, the invited paper that created much hostility towards Jensen.

“The hypothesis of God is a peculiar one, in that it supposes an infinitely incomprehensible object, although every hypothesis, as such, supposes its object to be truly conceived in the hypothesis.”

Charles Sanders Peirce (1839–1914) American philosopher, logician, mathematician, and scientist

Source: A Neglected Argument for the Reality of God (1908), II
Context: The hypothesis of God is a peculiar one, in that it supposes an infinitely incomprehensible object, although every hypothesis, as such, supposes its object to be truly conceived in the hypothesis. This leaves the hypothesis but one way of understanding itself; namely, as vague yet as true so far as it is definite, and as continually tending to define itself more and more, and without limit. The hypothesis, being thus itself inevitably subject to the law of growth, appears in its vagueness to represent God as so, albeit this is directly contradicted in the hypothesis from its very first phase. But this apparent attribution of growth to God, since it is ineradicable from the hypothesis, cannot, according to the hypothesis, be flatly false. Its implications concerning the Universes will be maintained in the hypothesis, while its implications concerning God will be partly disavowed, and yet held to be less false than their denial would be. Thus the hypothesis will lead to our thinking of features of each Universe as purposed; and this will stand or fall with the hypothesis. Yet a purpose essentially involves growth, and so cannot be attributed to God. Still it will, according to the hypothesis, be less false to speak so than to represent God as purposeless.

“Mr. Darwin's hypothesis is not, so far as I am aware, inconsistent with any known biological fact; on the contrary, if admitted, the facts of Development, of Comparative Anatomy, of Geographical Distribution, and of Palaeontology, become connected together, and exhibit a meaning such as they never possessed before; and I, for one, am fully convinced that if not precisely true, that hypothesis is as near an approximation to the truth as, for example, the Copernican hypothesis was to the true theory of the planetary motions.”

Thomas Henry Huxley (1825–1895) English biologist and comparative anatomist

Source: 1860s, Evidence as to Man's Place in Nature (1863), Ch.2, p. 127

“The existence of matter and energy in the universe did not require the violation of energy conservation at the assumed creation. In fact, the data strongly support the hypothesis that no such miracle occurred. If we regard such a miracle as predicted by the creator hypothesis, then the prediction is not confirmed.”

Victor J. Stenger book God: The Failed Hypothesis

Source: God: The Failed Hypothesis (2007), Chapter 4: 'Cosmic Evidence', p.117

“The day of the last hypothesis would be also the day of the last observation… An hypothesis displaced by new facts dies an honorable death. If it has itself summoned to its trial the facts by which it is annihilated, it deserves even a monument of gratitude.”

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Jacob Henle2

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