“If a due participation of office is a matter of right, how are vacancies to be obtained? Those by death are few; by resignation, none.”
Letter to Elias Shipman and others of New Haven (12 July 1801). Often misquoted as, "few die and none resign".
1800s, First Presidential Administration (1801–1805)
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Thomas Jefferson 456
3rd President of the United States of America 1743–1826Related quotes

Original: (it) Fate sempre attenzione a chiedere aiuto. Il vero aiuto si ottiene da poche, pochissime persone: quelle che ci mettono il cuore.
Source: prevale.net

“There really wasn’t much in a man’s life that mattered. But those few things mattered terribly.”
Section 3 “Admiralty”, Chapter IX (p. 200)
The Star Fox (1965)

Letter to Francis W. Gilmer (27 June 1816); The Writings of Thomas Jefferson edited by Ford, vol. 10, p. 32
1810s
Context: Our legislators are not sufficiently apprized of the rightful limits of their power; that their true office is to declare and enforce only our natural rights and duties, and to take none of them from us. No man has a natural right to commit aggression on the equal rights of another; and this is all from which the laws ought to restrain him; every man is under the natural duty of contributing to the necessities of the society; and this is all the laws should enforce on him; and, no man having a natural right to be the judge between himself and another, it is his natural duty to submit to the umpirage of an impartial third. When the laws have declared and enforced all this, they have fulfilled their functions, and the idea is quite unfounded, that on entering into society we give up any natural right.

Source: The Art of War, Chapter XIII · Intelligence and Espionage

"A Culture of Liberty" http://www.huffingtonpost.com/jacob-m-appel/a-culture-of-liberty_b_242402.html, The Huffington Post (2009-07-21)

“Few men in our history have ever obtained the Presidency by planning to obtain it.”
Diary (4 February 1879)
1870s