“The entire recent history of biology shows that we are, to a remarkable degree, the results of the interactions of an extremely complex array of molecules; and the aspect of biology that was once considered its holy of holies, the nature of the genetic material, has now been fundamentally understood in terms of the chemistry of its constituent nucleic acids, DNA and RNA, and their operational agents, the proteins.”

Introduction (p. 7)
The Dragons of Eden (1977)

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American astrophysicist, cosmologist, author and science ed… 1934–1996

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“The chemistry of genetics is primarily the chemistry and structure of the hereditary nucleic acid chains, DNA and RNA, and of the proteins whose structure they in turn control and the mechanism of this control.”

John R. Platt (1918–1992) American physicist

John R. Platt (1965). " Chemical Aspects of Genetics http://www.annualreviews.org/doi/abs/10.1146/annurev.pc.16.100165.002443?journalCode=physchem". In: Annual Review of Physical Chemistry.. Vol. 16. p. 503

“Among the seminal discoveries in biology in the twentieth century were the chemical nature and the three-dimensional structure of the genetic material, deoxyribonucleic acid, DNA.”

Albert L. Lehninger (1917–1986) American biochemist

Principles of Biochemistry, Ch. 1 : The Foundations of Biochemistry

“We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine.”

Linus Pauling (1901–1994) American scientist

Nobel Lecture (11 December 1954).
1940s-1960s

“Genetic determinism… On its interpretation depends the entire relation between biology and the social sciences.”

Edward O. Wilson book On Human Nature

On Human Nature (1978), Ch.3 Development

“The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.”

Francis Crick (1916–2004) British molecular biologist, biophysicist, neuroscientist; co-discoverer of the structure of DNA

Seattle: University of Washington Press, 1966, p. 10.
Of Molecules and Men (1966)

“I recognize nothing that is not material. In physics, chemistry and biology I see only mechanics. The Universe is nothing but an infinite and complex mechanism. Its complexity is so great that it borders on willfulness, suddenness, and randomness; it gives the illusion of free will possessed by conscious beings.”

Konstantin Tsiolkovsky (1857–1935) Russian and Soviet rocket scientist and pioneer of the astronautic theory

The Cosmic Philosophy, 1931

“[Biology has] become the paramount science, exceeding other disciplines, including physics and chemistry at least, in the creative tumult of its disciplines and disputations. […] I'll also be so bold at this point to suggest that we are now at the edge of establishing the two fundamental laws of biology: The first law is that all of the phenomena of biology, the entities and the processes, are ultimately obedient to the laws of physics and chemistry. Not immediately reducible to them, but ultimately consistent and in consilience with them, by a cause and effect explanation. The second law is that all biological phenomena, these entities and processes that define life itself, have arisen by evolution through natural selection.”

Edward O. Wilson (1929) American biologist

Talk at the 50th anniversary of New Scientist magazine (2006).

“Biology is the scientific study of life - in principle, anyway. In practice, biology is the scientific study of life on Earth based on carbon-chain chemistry. There is nothing in its charter that restricts biology to carbon-based life; it is simply that this is the only kind of life that has been available to study. Thus, theoretical biology has long faced the fundamental obstacle that it is impossible to derive general principles from single examples… Without other examples, it is difficult to distinguish essential properties of life - properties that would be shared by any living system - from properties that may be incidental to life in principle, but which happen to be universal to life on Earth due solely to a combination of local historical accident and common genetic descent.”

Christopher Langton (1949) American computer scientist

Source: Artificial Life (1989), p.2

“Since I set up the Unit, the area of solid state chemistry is no longer called so but is called chemistry of materials. This subject has become important. I set up this Unit in Bangalore much before the subject became important in the world. Now chemistry has two major directions:chemical biology and materials chemistry.”

C. N. R. Rao (1934) Indian chemist

Quoted in "In Conversation".

“In biology the Cartesian view of living organisms as machines, constructed from separate parts, still provides the dominant conceptual framework. Although Descartes' simple mechanistic biology could not be carried very far and had to be modified considerably during the subsequent three hundred years, the belief that all aspects of living organisms can be understood by reducing them to their smallest constituents, and by studying the mechanisms through which these interact, lies at the very basis of most contemporary biological thinking. This passage from a current textbook on modern biology is a clear expression of the reductionist credo: 'One of the acid tests of understanding an object is the ability to put it together from its component parts. Ultimately, molecular biologists will attempt to subject their understanding of cell structure and function to this sort of test by trying to synthesize a cell.”

Fritjof Capra book The Turning Point

Source: The Turning Point (1982), Ch. 4. The Mechanistic View of Life.

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