Episode 13: "The Long Childhood" 
The Ascent of Man (1973) 
Context: And I am infinitely saddened to find myself suddenly surrounded in the west by a sense of terrible loss of nerve, a retreat from knowledge into—into what? Into Zen Buddhism; into falsely profound questions about, Are we not really just animals at bottom; into extra-sensory perception and mystery. They do not lie along the line of what we are able to know if we devote ourselves to it: an understanding of man himself. We are nature’s unique experiment to make the rational intelligence prove itself sounder than the reflex. Knowledge is our destiny. Self-knowledge, at last bringing together the experience of the arts and the explanations of science, waits ahead of us.
                                    
“We never had a sounder intelligence in this Republic. He was the equal of Washington in making American liberty possible.”
            The Philosophy of Paine (1925) 
Context: Tom Paine has almost no influence on present-day thinking in the United States because he is unknown to the average citizen. Perhaps I might say right here that this is a national loss and a deplorable lack of understanding concerning the man who first proposed and first wrote those impressive words, 'the United States of America.' But it is hardly strange. Paine's teachings have been debarred from schools everywhere and his views of life misrepresented until his memory is hidden in shadows, or he is looked upon as of unsound mind.
We never had a sounder intelligence in this Republic. He was the equal of Washington in making American liberty possible. Where Washington performed Paine devised and wrote. The deeds of one in the Weld were matched by the deeds of the other with his pen.
        
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Thomas Edison 57
American inventor and businessman 1847–1931Related quotes
                                        
                                        " Whodunit? Who Meddled With Out Democracy? https://townhall.com/columnists/ilanamercer/2018/02/10/whodunit-who-meddled-with-our-democracy-n2446787" February 10, 2018, Townhall.com 
2010s, 2018
                                    
                                        
                                        Lecture II : The Universal Categories, §3. Laws: Nominalism, CP 5.60 
Pragmatism and Pragmaticism (1903) 
Context: There never was a sounder logical maxim of scientific procedure than Ockham's razor: Entia non sunt multiplicanda praeter necessitatem. That is to say; before you try a complicated hypothesis, you should make quite sure that no simplification of it will explain the facts equally well. No matter if it takes fifty generations of arduous experimentation to explode the simpler hypothesis, and no matter how incredible it may seem that that simpler hypothesis should suffice, still fifty generations are nothing in the life of science, which has all time before it; and in the long run, say in some thousands of generations, time will be economized by proceeding in an orderly manner, and by making it an invariable rule to try the simpler hypothesis first. Indeed, one can never be sure that the simpler hypothesis is not the true one, after all, until its cause has been fought out to the bitter end. But you will mark the limitation of my approval of Ockham's razor. It is a sound maxim of scientific procedure. If the question be what one ought to believe, the logic of the situation must take other factors into account. Speaking strictly, belief is out of place in pure theoretical science, which has nothing nearer to it than the establishment of doctrines, and only the provisional establishment of them, at that. Compared with living belief it is nothing but a ghost. If the captain of a vessel on a lee shore in a terrific storm finds himself in a critical position in which he must instantly either put his wheel to port acting on one hypothesis, or put his wheel to starboard acting on the contrary hypothesis, and his vessel will infallibly be dashed to pieces if he decides the question wrongly, Ockham's razor is not worth the stout belief of any common seaman. For stout belief may happen to save the ship, while Entia non sunt multiplicanda praeter necessitatem would be only a stupid way of spelling Shipwreck. Now in matters of real practical concern we are all in something like the situation of that sea-captain.
                                    
Letter to Theodore Petrasch (12 October 1864)
Source: Unless It Moves the Human Heart: The Craft and Art of Writing
                                        
                                        As quoted by Terry Dorian, Total Health and Restoration: A 180-Day Journey (2002), p. 49. Other versions include: 
[The] Constitution of this republic should make special provisions for medical freedom as well as religious freedom ... To restrict the art of healing to one class of men and deny equal privilege to another will constitute the Bastille of medical science. All such laws are un-American and despotic. They are fragments of monarchy and have no place in a republic. [in Robert L. Schwartz, "Laetrile: The Battle Moves into the Courtroom," American Bar Association Journal, February 1979, p. 226, no citation given] 
Unless we put medical freedom into the constitution the time will come when medicine will organize into an undercover dictatorship and force people who wish doctors and treatment of their own choice to submit to only what the dictating outfit offers. 
Laws restricting the practice of the healing art to one class of physicians and denying equal privileges to others, constitutes the Bastilles of Medicine, for they prevent progress. They are relics of Monarchy, and therefore have no place in a Republic. [in Thomas Morgan, "National Board of Health. The Other Side of the Question, As It Appears to Thomas Morgan," Youngstown Vindicator, 27 January 1911, p. 6] 
This quote is often cited with regards to Rush, and can rarely be found attributed to his autobiography, but does not exist in that book  http://books.google.com/books?id=EkTM9Kn9F4IC&q=%22into+the+constitution%22#v=onepage&q=%22into%20the%20constitution%22&f=false http://hpy.sagepub.com/content/16/1/89.abstract. The quote contains words and phrasing that seem anachronistic to late 18th century America. 
Misattributed
                                    
As quoted in [The Game of Nations, The Amorality of Power Politics, Copeland, Miles, 216, 1970, 4, Simon and Schuster]