“I am trying to convince people--not only the public, but lawmakers and people in power--that investing in the frontier of science, however remote it may seem in its relevance to what you're doing today, is a way of stockpiling the seed corns of future harvests of this nation… Advancing a frontier--history has shown--has advanced a culture ever since the industrial revolution got underway.”

Source: The Managerial Revolution, 1941, p. 220–221; As cited in Marcel van der Linden (2007, p. 83)

In an interview https://80000hours.org/podcast/episodes/holden-karnofsky-open-philanthropy/ with Robert Wiblin, February 2018; also quoted by Ben Pace in "Extended Quote on the Institution of Academia" https://www.lesswrong.com/posts/nXZi8efFArfk3u568/extended-quote-on-the-institution-of-academia and by Rob Bensinger in "Karnofsky on forecasting and what science does" https://www.lesswrong.com/posts/FhmWKE77qCPWJ63Y5/karnofsky-on-forecasting-and-what-science-does
Context: I think it's somewhat of a happy coincidence so far that most breakthroughs have been good. To say, I see a breakthrough on the horizon. Is that good or bad? How can we prepare for it? That's another thing academia is really not set up to do. Academia is set up to get the breakthrough. That is a question I ask myself a lot is here's an intellectual activity. Why can't it be done in academia? These days, my answer is if it's really primarily of interest to a very cosmopolitan philanthropist trying to help the whole future, and there's no one client and it's not frontier advancing, then I think that does make it pretty plausible to me that there's no one doing it. We would love to change that, at least somewhat, by funding what we think is the most important work.

With the observable fact that scientific knowledge makes our lives better when applied with concern for human welfare and environmental protection, there is no question that science and technology can produce abundance so that no one has to go without... Hopes for divine intervention by mythical characters are delusions that cannot solve the problems of our modern world. The future of the world is our responsibility and it depends upon decisions we make today. We are our own salvation or damnation.
Source: Designing the Future (2007), p. 10

Squire, Larry R. (ed). (2004). William Maxwell (Max) Cowan http://www.sfn.org/~/media/SfN/Documents/Autobiographies/c5.ashx. The History of Neuroscience in Autobiography. Volume 4. Elsevier. pp. 144-209. ISBN 0-12-660246-8.

Interview http://www.locusmag.com/1997/Issues/09/KSRobinson.html in Locus, (September 1997)
Context: Science fiction rarely is about scientists doing real science, in its slowness, its vagueness, the sort of tedious quality of getting out there and digging amongst rocks and then trying to convince people that what you're seeing justifies the conclusions you're making. The whole process of science is wildly under-represented in science fiction because it's not easy to write about. There are many facets of science that are almost exactly opposite of dramatic narrative. It's slow, tedious, inconclusive, it's hard to tell good guys from bad guys — it's everything that a normal hour of Star Trek is not.

All Gall Is Divided (1952)

Remarks to the Reichstag Committee of Foreign Affairs (7 October 1926), quoted in W. M. Knight-Patterson, Germany. From Defeat to Conquest 1913-1933 (London: George Allen and Unwin, 1945), p. 389
1920s

Founding Address (1876)
Context: The moral improvement of the nations and their individual components has not kept pace with the march of intellect and the advance of industry. Before the assaults of criticism many ancient strongholds of faith have given way, and doubt is fast spreading even into circles where its expression is forbidden. Morality, long accustomed to the watchful tutelage of faith, finds this connection loosened or severed, while no new protector has arisen to champion her rights, no new instruments been created to enforce her lessons among the people. As a consequence we behold a general laxness in regard to obligations the most sacred and dear. An anxious unrest, a fierce craving desire for gain has taken possession of the commercial world, and in instances no longer rare the most precious and permanent goods of human life have been madly sacrificed in the interests of momentary enrichment.

Geoffrey Rudolph Elton, The Parliament of England, 1559-1581 (1986)