“I am quite conscious that my speculations run quite beyond the bounds of true science. … I inferred that genera & Families with very few species (i. e. from Extinction) would be apt (not necessarily always) to have narrow ranges & disjoined ranges. You will not perceive, perhaps, what I am driving at & it is not worth enlarging on, — but I look at Extinction as common cause of small genera & disjoined ranges & therefore they ought, if they behaved properly & as nature does not lie to go together!”

—  Charles Darwin

The first sentence is often quoted in isolation http://www.conservapedia.com/Charles_Darwin, with the suggestion that Darwin is saying that his speculations concerning evolution "run quite beyond the bounds of true science." In fact, as the context makes clear, Darwin is referring to his speculations concerning the geographical ranges of genera with few species.
Other letters, notebooks, journal articles, recollected statements
Source: Letter http://www.darwinproject.ac.uk/letter/entry-2109 to Asa Gray, 18 June 1857

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Charles Darwin 161
British naturalist, author of "On the origin of species, by… 1809–1882

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