“The only difference between disappointment and depression is your level of commitment.”

— Marc Maron

Tickets Still Available (2006)
Variant: I think, in most cases, the difference between depression and disappointment is your level of commitment.

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Marc Maron15

Comedian 1963

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“I'm just saying, a lot of people are on medicine, they don't need to be. Because let's be honest folks, it isn't easy for anyone. And I think in most cases, the only difference between depression and disappointment is your level of commitment. And to be honest, in the day and age we live in now, if someone comes up to you and says, “I think you might be clinically depressed,” the proper response is, “Thank you, thank you very much. That means I’m awake." Is there any indication we shouldn’t be depressed— are you living on the same planet that I am? Did you ever think that depression is the reasonable human response to the crap we’re going through as a species, meant to propel us into the next evolutionary step, or at least into taking some different course of action so we might survive? Did you ever think that maybe it’s the happy people that are really screwed up in the head? Where’s that spin on the situation? Maybe it's those guys. "Hey, how ya doing?" "I don't know, I feel great, again!" "Really, well, that's creepy and weird. Maybe you should be on medication. Clearly you're self-centered, delusional, narcissistic. I don't know, but you're draining me with your happy. Could you move along because I'm doing the big work, creating a world that functions properly in my brain."”

Marc Maron (1963) Comedian

http://www.cc.com/video-clips/2ufif7/comedy-central-presents-bipolar-coaster
Comedy Central Presents (2007)