“I think the greatest sin in the world is bringing children into the world that have disease from their parents, that have no chance to be a human being, practically. Delinquents, prisoners, all sorts of things just marked when they're born. That to me is the greatest sin — that people can — can commit.”

Source: Dark Age (2019), Ch. 1: Till the Vale; Darrow

He cometido el peor pecado que uno puede cometer. No he sido feliz.
"El Remordimiento" [Remorse] in La moneda de hierro [The Iron Coin], as quoted in Borges at Eighty : Conversations (1982) edited by Willis Barnstone, also in Hispanic Literature Criticism : Allende to Jiménez (1994), p. 298

Source: One Minute Nonsense (1992), p. 139

"Everybody says it. The church, the government. It's against Nature, to give up, you've got to keep moving. That's the thing about you. You're not moving. You don't want to be here, selling old man Springer's jalopies. You want to be out there, learning something." He gestures toward the west. "How to hang glide, or run a computer, or whatever."
Rabbit is Rich (1981)

Source: Pearls of Wisdom

Misattributed
Source: Robert McAfee Brown https://en.wikipedia.org/wiki/Robert_McAfee_Brown. Preface for the 25th anniversary edition of Night https://en.wikipedia.org/wiki/Night_%28book%29. Page v, Bantam Books paperback; 1982 reissue edition.

The Decider (21 July 2007)

Quoted by M. Samuel, Prince of the Ghetto, 146.