“Our laws need to reflect the evolution of technology and the changing expectations of American society. This is why the Constitution is often called a “living” document. But we have a long way to go to get our modern privacy laws in line with modern technology.”

Maiden speech on 24 May 2005

The Guardian http://www.guardian.co.uk/technology/2012/apr/20/we-should-all-be-hactivists "We should all be hacktivists now", Column in the Guardian, 20 April 2012.
Attributed, In the Media

We the People interview (1996)
Context: Inevitably modern technology has polarized society. It has polluted the environment. It has disabled very simple native abilities and made people dependent on objects... Like an automobile which makes the world inaccessible, when actually in Latin "automobile" means "using your feet to get somewhere." The automobile makes it unthinkable. I was recently told, "You're a liar!" when I said to somebody I walked down the spine of the Andes. Every Spaniard in the sixteenth, seventeenth century did that. The idea that somebody could just walk! He can jog perhaps in the morning, but he can't walk anywhere! The world has become inaccessible because we drive there.

The ‘Bad’ Parts of Technology Cannot Be Separated From the ‘Good’ Parts, paragraph 121
Industrial Society and Its Future (1995)

Videodrome commentary track
Context: Technology isn’t really effective, it doesn’t really expose its true meaning, I feel, until it has been incorporated into the human body. And most of it does, in some way or another. Electronics. People wear glasses. They wear hearing aids that are really little computers. They wear pacemakers. They have their intestines modified. It’s really quite incredible what we’ve been able to do to the human body and really take it some place that evolution on its own could not take it. Technology has really taken over evolution. We’ve seized control of evolution ourselves without really quite being conscious of it. It’s no longer the environment that affects change in the human body, it’s our minds, it’s our concepts, our technology that are doing that.

Speech regarding Civil Liberties and the War on Terrorism (November 20, 2006)

Speech at the Opening Ceremony of the National Conference on Science (March 1978) (exerpts)

2010s, 2016, September, First presidential debate (September 26, 2016)

Attributed to Clarke on the internet, this has also been attributed to Isaac Asimov in published works.
Disputed