“We are by nature observers, and thereby learners. That is our permanent state.”
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Ralph Waldo Emerson 727
American philosopher, essayist, and poet 1803–1882Related quotes

This has also appeared in the alternate form: "What we observe is not nature itself, but nature exposed to our method of questioning."
Physics and Philosophy (1958)
Variant: What we observe is not nature itself, but nature exposed to our method of questioning.
Source: Physics and Philosophy: The Revolution in Modern Science

In der Quantenphysik dagegen bedeutet jede Beobachtung einen Eingriff in das Beobachtete; eine Zustandsveränderung am Beobachteten ist auf Grund der quantenphysikalischen Naturgesetze mit dem Beobachtungsprozess zwangslaüfig verknüpft. Also nicht ein sowieso, unabhängig von diesem Experiment vorhandener Tatbestand wird wahrgenommen, sondern wir selber rufen die Tatbestände hervor (oder: nötigen sie in bestimmter Richtung zu einer Klärung), die dann zur Wahrnehmung gelangen.
Quantenmechanische Bemerkungen zur Biologie und Psychologie, Erkenntnis, Vol. 4 (1934). p. 228.

Source: Course of Experimental Philosophy, 1745, p. v: Preface
Context: All the knowledge we have of nature depends upon facts; for without observations and experiments our natural philosophy would only be a science of terms and an unintelligible jargon. But then we must call in Geometry and Arithmetics, to our Assistance, unless we are willing to content ourselves with natural History and conjectural Philosophy. For, as many causes concur in the production of compound effects, we are liable to mistake the predominant cause, unless we can measure the quantity and the effect produced, compare them with, and distinguish them from, each other, to find out the adequate cause of each single effect, and what must be the result of their joint action.

No. 15
On the Interpretation of Nature (1753)
Context: There are three principal means of acquiring knowledge available to us: observation of nature, reflection, and experimentation. Observation collects facts; reflection combines them; experimentation verifies the result of that combination. Our observation of nature must be diligent, our reflection profound, and our experiments exact. We rarely see these three means combined; and for this reason, creative geniuses are not common.

Source: The Emergence Of Probability, 1975, Chapter 4, Evidence, p. 34.

"Science and Reality" (1931) Bios Vol. 2, No. 1 , p. 40