Pierre-Charles-Alexandre Louis was a French physician, clinician and pathologist known for his studies on tuberculosis, typhoid fever, and pneumonia, but Louis's greatest contribution to medicine was the development of the "numerical method", forerunner to epidemiology and the modern clinical trial, paving the path for evidence-based medicine. Wikipedia
“Without the aid of statistics nothing like real medicine is possible.”
Louis PCA. Medical statistics. Am J Med Sci 1837;21:525-8.
Quoted in Evidence-based medicine: old French wine with a new Canadian label? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1296268/, P K Rangachari, J R Soc Med. 1997 May; 90(5): 280–284.
“From the exposition of facts… we infer that bloodletting has had very little influence”
Researches on the effects of bloodletting... (1836)
Context: From the exposition of facts... we infer that bloodletting has had very little influence on the progress of pneumonitis, of erysipelas of the face, and of angina tonsillaris, in the cases under my observation; that its influence has not been more evident in the cases bled copiously and repeatedly, than in those bled only once and to a small amount; that, we do not at once arrest inflammations, as is too often fondly imagined; that, in cases where appears to be otherwise, it is undoubtedly owing, either to an error in diagnosis, or to the fact that the bloodletting was practised at an advanced period of the disease, when it had nearly run its course; that, it would be well, nevertheless, in inflammations of imminent hazard, pneumonitis, for instance, to try whether a first bleeding sufficient to produce syncope, from twenty-five to thirty ounces or more, would not be attended with greater success; and finally that, wherever I have been able to compare the effect of general, with that of local bleeding by leeches, the superiority of the former has appeared to me demonstrated.<!--p. 22
Letter to Jean Cruveilhier (1837), as quoted by William Coleman, Death is a Social Disease: Public Health and Political Economy in Early Industrial France (1982)
Recherches sur les effets de la saignée dans quelques maladies inflammatoires, et sur l'action de l'émétique et des vésicatoires dans la pneumonie (1835) as quoted by William Coleman, Death is a Social Disease: Public Health and Political Economy in Early Industrial France (1982)
p, 125
Researches on the effects of bloodletting... (1836)
p, 125
Researches on the effects of bloodletting... (1836)
